| Player | Goals | Games | Premier League clubs |
| Alan Shearer | 260 | 441 | Blackburn Rovers, Newcastle United |
| Wayne Rooney | 208 | 491 | Everton, Manchester United |
| Andy Cole | 187 | 415 | Newcastle United, Manchester United, Blackburn Rovers, Fulham, Manchester City, Portsmouth, Sunderland |
| Sergio Aguero | 184 | 275 | Manchester City |
| Harry Kane | 178 | 274 | Tottenham Hotspur |
| Frank Lampard | 177 | 609 | West Ham United, Chelsea, Manchester City |
| Thierry Henry | 175 | 258 | Arsenal |
| Robbie Fowler | 163 | 379 | Liverpool, Leeds United, Manchester City, Blackburn Rovers |
| Jermain Defoe | 162 | 496 | West Ham United, Tottenham Hotspur, Portsmouth, Sunderland, Bournemouth |
| Michael Owen | 150 | 326 | Liverpool, Newcastle United, Manchester United, Stoke City |
| Les Ferdinand | 149 | 351 | Queens Park Rangers, Newcastle United, Tottenham Hotspur, West Ham United, Leicester City, Bolton Wanderers |
| Teddy Sheringham | 146 | 418 | Nottingham Forest, Tottenham Hotspur, Manchester United, Portsmouth, West Ham United |
| Robin Van Persie | 144 | 280 | Arsenal, Manchester United |
| Jamie Vardy | 128 | 263 | Leicester City |
| Jimmy Floyd Hasselbaink | 127 | 288 | Leeds United, Chelsea, Middlesbrough, Charlton Athletic |
| Robbie Keane | 126 | 349 | Coventry City, Leeds United, Tottenham Hotspur, Liverpool, West Ham United, Aston Villa |
| Nicolas Anelka | 125 | 364 | Arsenal, Liverpool, Manchester City, Bolton Wanderers, Chelsea, West Bromwich Albion |
| Dwight Yorke | 123 | 375 | Aston Villa, Manchester United, Blackburn Rovers, Birmingham City, Sunderland |
| Steven Gerrard | 120 | 504 | Liverpool |
| Romelu Lukaku | 118 | 272 | Chelsea, West Bromwich Albion, Everton, Manchester United |
| Mohamed Salah | 117 | 186 | Chelsea, Liverpool |
| Ian Wright | 113 | 213 | Arsenal, West Ham United |
| Dion Dublin | 111 | 312 | Manchester United, Coventry City, Aston Villa |
| Emile Heskey | 110 | 516 | Leicester City, Liverpool, Birmingham City, Wigan Athletic, Aston Villa |
| Ryan Giggs | 109 | 632 | Manchester United |
| Peter Crouch | 108 | 468 | Aston Villa, Southampton, Liverpool, Portsmouth, Tottenham Hotspur, Stoke City, Burnley |
| Sadio Mane | 107 | 256 | Southampton, Liverpool |
| Paul Scholes | 107 | 499 | Manchester United |
| Darren Bent | 106 | 276 | Ipswich Town, Charlton Athletic, Tottenham Hotspur, Sunderland, Aston Villa, Fulham |
| Raheem Sterling | 106 | 314 | Liverpool, Manchester City |
| Didier Drogba | 104 | 254 | Chelsea |
| Matt Le Tissier | 100 | 270 | Southampton |
| Cristiano Ronaldo | 100 | 223 | Manchester United |
